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KMID : 0895820200300030045
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Journal of Oriental Rehabilitation Medicine
2020 Volume.30 No. 3 p.45 ~ p.56
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The Effects of ChondroT on Thrombus in FeCl3-induced Rats
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Kim Ji-Hoon
Kim Sun-Gil
Kim Joo-Il
Yoon Chang-Suk
Choi Ji-Min
Na Chang-Su
Kim Seon-Jong
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Abstract
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Objectives : This study was designed to investigate the effects of ChondroT on thrombus in FeCl3-induced rats.
Methods : We exposed FeCl3 to rat’s carotid artery to induce thrombus. Specimens were divided in 5 groups; Intact, Control, ASA10 (aspirin 10 mg/kg), CT100 (ChondroT 100 mg/kg), and CT200 (ChondroT 200 mg/kg), each n=6. We investigated thromboxane, platelet activating factor (PAF), histological change, lipid metabolism, transaminase, leukocyte, erythrocyte and thrombocyte level.
Results : In ASA10, CT200 groups, there was significants decrease in both thromboxane level and total cholesterol level, compared to control group and there were significant histological changes of blood vessel, compared to control group. In CT200 group, there was significant decrease in PAF level, compared to control group (p<0.05). In ASA10, CT200 groups, triglycerides level tended to decrease, compared to control group.
Conclusions : Based on these results, it could be suggested that ChondroT was effective on thrombus in FeCl3-induced rats, and further study is needed to conduct a rigorous clinical research.
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KEYWORD
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ChondroT, Thrombosis, Herbal medicine, FeCl3
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